Journal of Biomedical and Clinical Research 17(1): 115-126, doi: 10.3897/jbcr.e123690
Thromboprophylaxis during pregnancy for prevention of adverse complications in patients with inherited thrombophilia: a literature review
Zlatko Kirovakov‡, Elitsa Gyokova‡, Nadezdha Hinkova‡, Emiliana Konova‡‡ Medical University of Pleven, Pleven, Bulgaria
Corresponding author: Zlatko Kirovakov ( kirovakov@yahoo.com ) Academic editor: Zornitsa Kamburova © Zlatko Kirovakov, Elitsa Gyokova, Nadezdha Hinkova, Emiliana Konova. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation:
Kirovakov Z, Gyokova E, Hinkova N, Konova E (2024) Thromboprophylaxis during pregnancy for prevention of adverse complications in patients with inherited thrombophilia: a literature review. Journal of Biomedical and Clinical Research 17(1): 115-126. https://doi.org/10.3897/jbcr.e123690 |  |
Abstract
Compared with non-pregnant women, pregnancy alone carries a three- to fivefold higher risk of venous thromboembolism (VTE). Despite the increasing use of low-molecular-weight heparin in identified high-risk patients, pulmonary embolism is still the leading cause of maternal mortality. However, evidence for optimal use of thromboprophylaxis is scarce. Thrombophilia (hereditary or acquired) is thought to predispose to both VTE and is also associated with complications of pregnancy, such as recurrent miscarriages and preeclampsia. This review discusses the current evidence for optimal thromboprophylaxis during pregnancy by focusing primarily on VTE prevention strategies, the potential to prevent recurrent complications during pregnancy with low molecular weight heparin (LMWH), aspirin, and Nattokinase in pregnant women with congenital thrombophilia.
Keywords
Aspirin, low molecular weight heparin, nattokinase, thrombophilia