Journal of Biomedical and Clinical Research 7(2): 88-92, doi: 10.1515/jbcr-2015-0131
Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate
expand article infoSofiya L. Ivanova, Dimitrichka J. Dimitrova, Metodi H. Petrichev, Liliana I. Parvanova, Georgi Sl. Kalistratov, Lubomir T. Vezenkov
© Sofiya Ivanova, Dimitrichka Dimitrova, Metodi Petrichev, Liliana Parvanova, Georgi Kalistratov, Lubomir Vezenkov.
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Citation: Ivanova SL, Dimitrova DJ, Petrichev MH, Parvanova LI, Kalistratov GSl, Vezenkov LT (2014) Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate. Journal of Biomedical and Clinical Research 7(2): 88-92. https://doi.org/10.1515/jbcr-2015-0131
Open Access
Abstract
The pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two approaches – compartmental method and non-compartmental analysis using pharmacokinetic software (TopFit, v. 2.0). After the intraingluvial application, zinc was rapidly absorbed (t1/2abs. =0.1040.02 h) by the alimentary system of birds attaining Cmax of 63.603.94 mol/ml by hour 0.77 (compartmental method) and Cmax =69.274.35 mol/ml by hour 0.92 h (non-compartmental method). It is characterized with a long biological half-life (t1/2) of 13.821.63 h (compartmental analysis) and 15.961.73 h (non-compartmental analysis) and long mean residence times (MRT) 20.122.35 h and 23.002.50 h, respectively. The distribution in blood and extracellular fluid was good as seen from Vd(area) values 0.770.05 l/kg (compartmental analysis) and 0.650.05 l/kg (non-compartmental analysis).
Keywords
pharmacokinetics, chickens, zinc aspartate