Journal of Biomedical and Clinical Research 8(2): 124-132, doi: 10.1515/jbcr-2015-0162

SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women

Regina S. Komsa-Penkova, Georgi M. Golemanov, Boris D. Cankov, Lubomir C. Beshev, Petar D. Ivanov, Pencho T. Tonchev

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Citation: Komsa-Penkova RS, Golemanov GM, Cankov BD, Beshev LC, Ivanov PD, Tonchev PT (2015) SND Rs1799889(-) In The Promotor Of The Plasminogen Activator Inhibitor-1 Gene Contributes To The Risk Of DVT In Women. Journal of Biomedical and Clinical Research 8(2): 124-132. https://doi.org/10.1515/jbcr-2015-0162

Abstract

The incidence of deep venous thrombosis (DVT) depends on the specific genotype, inheritance of prothrombotic polymorphisms and the influence of environmental risk factors. Rs1799889(-) polymorphism in the promotor of PAI-1 gene has been described as a risk factor for hypercoagulable state. Objective: To evaluate the contribution of thrombophilic rs1799889 (-) in the promotor of PAI-1 gene on the incidence of DVT in women and men in groups below and above 45 years of age. Тhere was significantly higher rs1799889 (-) polymorphism carriage among female patients with DVT vs controls (Chi squared =5.506, OR=2.170, p=0.021) but not in male patients (Chi squared =0.090 OR=1.147, p=0.825). A significant contribution of rs1799889 (-) polymorphism to early onset of the disease was found in female patients aged 45+ and carriers of the polymorphism (Chi squared =7.476, p=0.006), but not in young women.

Keywords

deep venous thrombosis, thrombophilia, Rs1799889(-)s, PAI-1