Journal of Biomedical and Clinical Research 14(2): 169-177, doi: 10.2478/jbcr-2021-0021
Single-Dose Cold Modified Bretschneider Solution for Myocardial Protection in the Surgical Treatment of Patients with Aortic Valve Stenosis and Left Ventricular Hypertrophy
expand article infoPetar H. Uzov, Chavdar M. Ivanov
© Petar Uzov, Chavdar Ivanov.
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Citation: Uzov PH, Ivanov CM (2021) Single-Dose Cold Modified Bretschneider Solution for Myocardial Protection in the Surgical Treatment of Patients with Aortic Valve Stenosis and Left Ventricular Hypertrophy. Journal of Biomedical and Clinical Research 14(2): 169-177. https://doi.org/10.2478/jbcr-2021-0021
Open Access
Abstract
Aortic valve stenosis (AS) is predominantly caused by degenerative calcification in patients over 70 years. It obstructs the left ventricular outflow tract. The result is concentric left ventricular hypertrophy (LVH) wall stress and ischemia-induced myocardial fibrosis. [1] According to the European Association of Cardiothoracic Surgery, all high-grade AS patients are indicated for Aortic valve intervention [2]. One of the most recommendable methods for myocardial protection during surgical aortic valve replacement is antegrade delivery of cold crystalloid cardioplegia. Our retrospective study included 173 operated patients with AS and LVH. We observed the MB fraction of the enzyme creatine phosphokinase (CPK-MB) as a postoperative marker for myocardial hypoprotection in different patients. Our results showed that a single dose of modified Bretschnaider solution provided safe and long enough myocardial protection during conventional and minimally invasive aortic valve replacement in patients with AS and LVH [3].
Keywords
antegrade cardioplegia, Bretschneider solution, myocardial protection